每日一题_2023.04.19

A 30-year-old woman finds a lump in her right breast during a monthly self-examination. Diagnostic mammography reveals a 2-cm mass with uneven borders and spiculated calcifications; this finding is suspicious for malignancy. A biopsy is performed. The report identifies ductal carcinoma in situ, and a lumpectomy is performed. The pathology report further states that the malignant tissue is positive for human epidermal growth factor 2/neu receptor, but negative for estrogen and progesterone receptors. Which of the following therapies is specifically targeted to treat this patient’s breast cancer?

一名30岁的妇女在每月一次的自我检查中发现右乳房有一个肿块。诊断性乳房x光检查显示2厘米肿块，边界不均匀，有针状钙化;这一发现可疑为恶性肿瘤。进行活组织检查。报告确定导管原位癌，并进行乳房肿瘤切除术。病理报告进一步指出，恶性组织对人表皮生长因子2/新受体呈阳性，但对雌激素和孕激素受体呈阴性。以下哪一种治疗方法是专门针对该患者的乳腺癌的?

(A) Bevacizumab 贝伐单抗

(B) Cyclophosphamide 环磷酰胺

(C) Doxorubicin 阿霉素

(D) Tamoxifen 它莫西芬

(E) Trastuzumab 曲妥珠单抗

答案解析：

曲妥珠单抗是一种针对人表皮生长因子受体2 (HER2)的单克隆抗体，可杀死过表达HER2的乳腺癌细胞。该患者的乳腺癌HER2/neu受体阳性，因此她可能对化疗药物曲妥珠单抗有阳性反应。

正确答案：E