临床研究
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CCM:新斯的明作为脓毒性休克辅助治疗对减轻促炎细胞因子的作用：一项随机对照试验
Abstract Objective: The cholinergic anti-inflammatory pathway (ChAP) is the key regul…
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CCM:免疫功能受损脓毒症患者炎症分子亚型的预后相关性
Abstract Objectives: Hyperinflammatory and hypoinflammatory molecular subphenotypes i…
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CCM:经皮扩张气管切开术中的纤维支气管镜监测：一项多中心随机对照试验——FIBERTRACH随机临床试验
Abstract Objectives: To assess the prevalence of perioperative complications of endoscopic…
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CC:静脉-静脉体外膜肺氧合（venovenous ECMO）中血小板减少的发生率、动态变化及其临床影响：来自多中心观察性PROTECMO研究的见解
背景 血小板减少症是体外膜肺氧合（ECMO）期间公认的出血危险因素。本研究旨在明确静脉-静脉体外膜肺氧合（VV-ECMO）治疗期间血小板减少症及血小板输注的发生率、危险因素和临床相…
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CCM:炎症亚型在免疫功能低下脓毒症患者的预后相关性
Abstract Objectives: Hyperinflammatory and hypoinflammatory molecular subphenotypes i…
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NEJM:急性低氧性呼吸衰竭选择高流量或标准氧疗？
Abstract Background Data are needed on the effect of oxygen delivered through a high-flow …
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CC:重症监护病房肝脓肿预后研究（POLAIR）：一项多中心观察性研究
Abstract Background Liver abscess (LA) is a rare but potentially serious condition with a …
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CCM:新斯的明作为辅助治疗在感染性休克中对减轻促炎细胞因子作用：一项随机对照试验
Abstract Objective: The cholinergic anti-inflammatory pathway (ChAP) is the key regul…
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JAMA Network Open:医生在早期脓毒症管理中的差异
Abstract Importance: Prompt antimicrobial therapy is essential in sepsis, but acceler…
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ICM:根据重症监护室入院时急性肾损伤严重程度划分的健康结局：一项基于人群的队列研究
Abstract Purpose: The presence and severity of acute kidney injury (AKI) upon ICU adm…
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JAMA Netw Open：严重高钠血症患者的纠正速率与全因死亡率
Abstract Importance: Hypernatremia is common among hospitalized patients and is associated…
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JAMA Network Open:早期脓毒症所致低血压的外周升压药应用
Abstract Importance: Evidence supporting the safety of infusing vasopressors through perip…
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JAMA:左西孟旦促进严重心源性休克患者脱离体外膜肺氧合（ECMO）的LEVOECMO随机临床试验
Abstract Importance: Levosimendan may facilitate weaning from venoarterial extracorpo…
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CC:心脏骤停后结果预测的自动灰质-白质比纵向评估
Abstract Background The gray-white matter ratio (GWR) on head CT is a well-established mar…
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NEJM Evidence:急性胸综合征预测评分的验证与应用
背景：血管闭塞危象（VOC）是镰状细胞病最常见的表现，而急性胸综合征（ACS）是其常见并发症，具有较高的死亡风险。本研究的目的是验证先前开发的PREdictive SEVerity…
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CC:降钙素原轨迹作为识别高死亡风险脓毒症患者的有效工具
脓毒症是一种严重疾病，对全球医疗系统造成沉重负担。鉴于脓毒症患者之间存在显著的异质性，识别高死亡风险群体至关重要[1]。降钙素原（PCT）是一种被广泛认可的评估脓毒症严重程度并指导…
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ICM:利用生命体征轨迹构建和验证脓毒症新亚型
Abstract Purpose: Sepsis is a heterogeneous syndrome and identification of sub-phenotypes …
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JAMA：七天与四天更换输液器间隔及导管相关感染的比较
Abstract Importance: Catheter-related bloodstream infections (CRBSIs) are associated …
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CCM:静脉-动脉体外膜肺氧合期间的神经系统并发症及其对6个月以患者为中心结局的影响
Abstract Objectives: Venoarterial extracorporeal membrane oxygenation (ECMO) is assoc…
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JAMA:低分子肝素联合胰岛素治疗高甘油三酯血症性急性胰腺炎：一项随机临床试验
Abstract Importance: Although insulin is widely used for early lipid lowering in hypertrig…
