A 50-year-old man presents to the emergency department because of substernal chest pain that started four hours ago and is becoming severe. After a thorough work-up he is diagnosed with an acute myocardial infarction (MI). Which of the following laboratory test elevations is most specific for MI?
一名50岁男性4小时前开始胸骨后胸痛,并逐渐加重,因此到急诊科就诊。经过全面检查,他被诊断为急性心肌梗塞(MI)。下列哪项实验室检查结果升高对MI最有特异性?
(A) Alanine aminotransferase 丙氨酸氨基转移酶
(B) Aspartate aminotransferase 天冬氨酸氨基转移酶
(C) Creatine kinase-MB fraction CK-MB
(D) Lactate dehydrogenase 乳酸脱氢酶
(E) Troponin I 肌钙蛋白I
答案解析:
肌钙蛋白是一种沿肌小节发现的有助于肌肉收缩的蛋白质。肌肉损伤时,肌钙蛋白会渗漏到血清中。不同的分数对不同的组织表现出不同的特异性。在心肌组织中,肌钙蛋白I被证明比心肌酶,尤其是CK-MB,具有更高的特异性和同样的敏感性。
正确答案:E
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