A 76-year-old man presented to the dermatology clinic with a 2-day history of blood-filled blisters on the tongue. He reported no prior trauma or other bleeding symptoms. Physical examination was notable for hemorrhagic bullae on the tongue and gingiva, and purpura on the arms and legs. Which of the following lab abnormalities is most likely present?
一名76岁男性因舌头充血水疱2日到皮肤科门诊就诊。患者自诉既往无外伤或其他出血症状。体格检查发现舌和牙龈有出血性大疱,手臂和腿部有紫癜。下列哪个实验室异常最有可能出现?
A. Anemia 贫血
B. Elevated PT and PTT
C. Leukopenia 白细胞减少症
D. Thrombocytopenia 血小板减少症
E. Vitamin C deficiency
答案解析:
外周血涂片示血小板减少伴巨核细胞,骨髓活检示巨核细胞增多,诊断为免疫性血小板减少症。原发性免疫性血小板减少症是在排除了其他原因引起的血小板减少症和继发性免疫性血小板减少症之后做出的排除性诊断。患者接受了8周逐渐减量的泼尼松龙治疗。12周随访时,他的皮肤黏膜病变减轻,血小板计数恢复正常。
正确答案:D
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