A 68-year-old woman with rosacea presented to clinic with a 6-week history of asymptomatic dark patches on her arms and legs. Two weeks before the onset of the skin changes, she had started treatment for the rosacea. Physical examination is shown. What is the most likely causative agent?
一位68岁女性,患有酒渣鼻(玫瑰痤疮),因四肢出现无症状的暗色斑块6周前来就诊。在皮肤改变出现前两周,她开始接受酒渣鼻的治疗。体格检查如图所示。最可能的致病因素是什么?

A. Oral minocycline口服米诺环素
B. Phototherapy光疗
C. Topical oxymetazoline外用羟甲唑啉
D. Topical metronidazole外用甲硝唑
E. Topical tacrolimus外用他克莫司
答案解析:
正确答案是口服米诺环素。患者被诊断为米诺环素引起的色素沉着。组织色素沉着是米诺环素的已知不良反应,通常在治疗数月后出现,但少数情况下也可能在较短疗程中发生。本例被诊断为II型色素沉着——表现为四肢伸侧正常皮肤呈蓝灰色改变。已建议该患者停用米诺环素,并避免日晒。
正确答案:A
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