An 11-year-old girl presented to the orthopedic clinic with a 1-month history of right thigh pain that worsened at night. Physical examination was notable for soft-tissue swelling over the distal thigh and limited range of motion of the knee on the right side. Which of the following is the most likely diagnosis?
一名 11 岁女孩因右大腿疼痛 1 个月就诊于骨科门诊，其疼痛在夜间加重。体格检查发现右大腿远端软组织肿胀，且右侧膝关节活动受限。以下哪项是最可能的诊断？
A. Aneurysmal bone cyst动脉瘤样骨囊肿
B. Chondrosarcoma软骨肉瘤
C. Osteoid Osteoma骨样骨瘤
D. Osteomyelitis骨髓炎
E. Osteosarcoma骨肉瘤
答案解析：
影像学检查显示股骨远端干骺端存在成骨性病灶，边界不清并伴有皮质破坏。随后的膝关节磁共振成像（MRI）及骨活检证实了高级别骨肉瘤的诊断。骨肉瘤是儿童中最常见的原发性恶性骨肿瘤。由于其在该发育阶段骨骼生长迅速，该病通常发生于第二个十年（即 10-20 岁）期间。
正确答案：E
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