A 30-year-old man was admitted to the hospital with 2 weeks of rash and fever that had started one month after taking a course of trimethoprim–sulfamethoxazole for the treatment of folliculitis. Physical examination was notable for fever, a diffuse morbilliform rash, submandibular lymphadenopathy, and facial erythema with periorbital sparing. Four days after admission, facial edema developed. Labs showed elevated absolute eosinophils and aminotransferase levels.
What’s the most likely diagnosis?
A. Acute generalized exanthematous pustulosis
B. Drug reaction with eosinophilia and systemic symptoms
C. Erythroderma
D. Hypereosinophilic syndrome
E. Stevens-Johnson syndrome/toxic epidermal necrolysis
答案解析：
正确答案是药物反应伴嗜酸性粒细胞增多和全身症状。给予全身糖皮质激素及环孢素治疗，症状改善，建议今后避免使用含磺胺类抗生素。
正确答案：B
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