A 30-year-old man is involved in a motorcycle accident and is pronounced dead on arrival at the emergency department. A cross-section of his coronary arteries at autopsy is shown in the image. Under normal circumstances, which substance is produced in the innermost cells of the layer (ie, the layer closest to the blood) where these plaques develop?
一名30岁的男子发生摩托车事故,在到达急诊室时被宣布死亡。图中显示了尸检时他冠状动脉的横切面。在正常情况下,斑块形成的那一层(即最接近血液的那一层)的最内层细胞产生什么物质?
(A) Collagen胶原蛋白
(B) Fibrillin 纤维蛋白原
(C) Hemoglobin 血红蛋白
(D) Macrophage colony-stimulating factor )巨噬细胞集落刺激因子
(E) Nitric oxide一氧化氮
答案解析:
图中显示的斑块是动脉粥样硬化。这些细胞外脂质病变在动脉壁内膜内形成。内膜位于动脉的管腔侧;它与血液是最“亲密”的。因此内膜最内层的细胞是内皮细胞。在非病理性状态下,内皮细胞通过释放抗血栓因子(如前列环素和一氧化氮)来防止斑块形成。
正确答案:E
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