每日一题_2023.06.24

A 26-year-old woman visits her physician with complaints of vaginal bleeding after sexual intercourse. She started menses at age 14 years and has 32-day cycles. She acknowledges having unprotected sex with multiple partners. Cytologic specimens are taken from the cervix and vagina. On microscopy, cervical cells have large nuclei with open chromatin; several cells have mitotic figures. What additional findings would most likely be present in the specimens that account for these findings?

一名26岁女性因性交后阴道出血就诊。患者14岁开始月经，周期为32天。她承认与多名伴侣发生过无保护措施的性行为。细胞学标本取自宫颈和阴道。显微镜下，宫颈细胞细胞核大，染色质开放；若干细胞有有丝分裂象。在解释这些发现的标本中，最有可能出现的其他发现是什么?

(A) Double-stranded DNA virus 双链DNA病毒

(B) Gram-negative diplococci 革兰阴性双球菌

(C) Gram-positive cocci 革兰阳性球菌

(D) Single-stranded RNA 单链RNA

(E) Squamous cells covered with bacteria 覆盖细菌的鳞状细胞

答案解析：

显微镜检查的结果表明正常细胞的恶性转化。增加的核质比、开放的染色质和有丝分裂象表明细胞分裂活跃。考虑到患者的多个性伴侣史和性交后出血，这些细胞可能表明存在宫颈癌。子宫颈癌通常与人乳头瘤病毒感染有关。在细胞学检查过程中，可以通过各种方法分离病毒。是一种双链DNA病毒。

正确答案：A