An 83-year-old woman with a history of type 2 diabetes mellitus presented with a 4-month history of a pruritic rash on her back. Physical examination showed a linear array of crateriform lesions containing crusted material on an erythematous base. A skin biopsy showed a cup-shaped ulceration with transepidermal elimination of basophilic collagen and with cellular debris. What is the most likely diagnosis?
患者女性,83岁,2型糖尿病病史,背部皮疹伴瘙痒4个月。体格检查显示,红斑基础上的线状陨石坑样病变中含有结痂物质。皮肤活检显示杯状溃疡,嗜碱性胶原经表皮清除,并有细胞碎片。最有可能的诊断是什么?
A. Dermatofibroma 皮肤纤维瘤
B. Folliculitis 毛囊炎
C. Keratoacanthoma 黑棘皮病
D. Reactive perforating collagenosis 反应性穿孔性胶原病
E. Prurigo nodularis结节性痒疹
答案解析:
正确答案是反应性穿孔性胶原病。这种疾病既可以是遗传的,也可以是后天获得的,就像在这个病例中,并且与糖尿病等全身性疾病相关。以真皮结缔组织穿过表皮穿孔为特征。治疗包括治疗基础疾病和减少瘙痒,而瘙痒很可能引发皮肤病的发展和持续。
正确答案:D
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