A 35-year-old man presented to the dermatology clinic with a 4-day history of anxiety, insomnia, and resting tremor of the hands and feet. One month before presentation, the patient had begun taking multidrug therapy for leprosy. On physical examination, bluish discoloration of the lips and tongue was observed. What drug is the most likely cause of this presentation?
一名35岁男性因焦虑、失眠和手足静止性震颤4日到皮肤科门诊就诊。就诊前1个月，患者已开始接受麻风病多药治疗。体格检查可见唇舌发青。最可能引起这种表现的药物是什么?
A. Clofazimine氯法齐明
B. Dapsone氨苯砜
C. Rifampin利福平
D. Thalidomide沙利度胺
E. Salicylates水杨酸盐
答案解析：
患者在葡萄糖-6-磷酸脱氢酶缺乏检测呈阴性后开始服用氨苯砜。嘴唇和舌头的青紫颜色表明中枢性发绀。青紫最常见于表皮较薄和血液供应丰富的部位，如耳朵、鼻子、嘴唇和口腔粘膜。对于动脉血氧饱和度降低或血红蛋白异常，应警惕发绀。初次就诊并停止氨苯砜治疗2天后，患者症状缓解。
正确答案：B
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