A 42-year-old man on prolonged immunosuppressive therapy for chronic graft-versus-host disease after stem-cell transplantation for acute lymphoblastic leukemia presented to clinic with a 2-week history of urinary frequency and weak stream. Physical examination was notable for several small papules on the penile shaft. Urinalysis showed 9 white cells per high-power field, and a urine culture was negative. Testing for human immunodeficiency virus was also negative. Resected urethral tissue showed papillomatous squamous proliferation with koilocytic atypia. Which of the following causes this condition?
一名42岁男性，因急性淋巴细胞白血病接受干细胞移植后，长期服用免疫抑制剂治疗慢性移植物抗宿主病。患者因尿频、尿流变细2周就诊于诊所。体格检查发现阴茎干上有数个小的丘疹。尿液分析显示每高倍视野有9个白细胞，尿培养阴性。人类免疫缺陷病毒检测也为阴性。切除的尿道组织显示乳头状鳞状增生伴挖空细胞异型性。以下哪项导致了该病症？
A. Herpes simplex virus单纯疱疹病毒
B. Human papillomavirus人乳头瘤病毒
C. Poxvirus痘病毒
D. Treponema pallidum梅毒螺旋体
E. Ureaplasma urealyticum解脲支原体
答案解析：
关键病理特征：koilocytic atypia（挖空细胞异型性）这是HPV感染最经典、最具特异性的病理学标志。挖空细胞（Koilocyte）就是被HPV感染后发生空泡变性的鳞状上皮细胞。结合题目中提到的”papillomatous squamous proliferation”（乳头状鳞状增生），这完全符合尖锐湿疣（Condyloma acrochuminatum）的病理表现。
正确答案：B
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