A 50-year-old Chinese immigrant presents to his primary care physician complaining of fever, night sweats, and blood-tinged sputum for the past three weeks. X-ray of the chest is remarkable for calcification in the right upper lobe. Which of the following adverse effects is commonly associated with a drug used in the treatment of this man’s disease?
一名50岁的中国移民到他的初级保健医生那里,抱怨过去三周发烧、盗汗和带血的痰。胸部x线片显示右肺上叶钙化。下列哪项不良反应通常与用于治疗该患者疾病的药物相关?
(A) Blue and yellow color blindness 蓝黄色盲
(B) Myalgias肌痛
(C) Numbness and tingling麻木和刺痛
(D) Ophthalmoplegia眼肌麻痹
(E) Renal failure 肾功能衰竭
答案解析:
该患者的症状发热、盗汗和咯血符合结核病(TB)。右肺上叶钙化为Ghon复合体,即结核肉芽肿(Ghon灶),周围肺叶和肺门周围淋巴结受累。结核病是由结核分枝杆菌引起的,可以用抗酸染色来观察。目前活动性结核病的治疗采用多药联合方案,包括利福平、异烟肼、吡嗪酰胺和乙胺丁醇。在列出的不良反应中,只有麻木和刺痛(周围神经病变)通常与异烟肼和乙胺丁醇相关。补充维生素B6可预防或逆转INH-相关性周围神经病变。
正确答案:C
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