每日一题_2023.02.16

An 80-year-old woman was admitted to the intensive care unit with severe second- and third-degree burns. On laboratory studies, she was noted to have a platelet count of 930,000 per cubic millimeter. Manual analysis of a subsequent peripheral-blood smear identified a platelet count of 115,000 per cubic millimeter. What is the cause for this discrepancy?

一名80岁女性因严重二、三度烧伤入住重症监护病房。实验室检查发现她的血小板计数为930,000 / mm3。对随后的外周血涂片进行的手工分析发现，血小板计数为115,000 / mm3。造成这种差异的原因是什么?

A. Pseudothrombocytopenia due to giant platelets 巨大血小板引起的假性血小板减少症

B. Pseudothrombocytopenia due to plate clumping associated with EDTA 与EDTA相关的板凝块引起的假性血小板减少症

C. Pseudothrombocytosis due to cryoglobulin-related interference by cryoprecipitates 由冷沉淀相关的冷球蛋白干扰引起的假性血小板增多症

D. Pseudothrombocytosis due to presence of microorganisms 由微生物存在引起的假性血小板增多症

E. Pseudothrombocytosis due to red cell fragments 红细胞碎片引起的假性血小板增多症

答案解析：

正确答案是红细胞碎片引起的假性血小板增多症。在严重烧伤患者中，热引起的红细胞膜破裂可产生较小的细胞，这些细胞可能被自动计数器错误地计数为血小板。

正确答案：E